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Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm (4). GATA-6的基因敲除会引起心脏导管的形成缺失，也不能发育胚外内胚层，这些会导致胚胎致死[4]。 www.cst-c.com.cn