frazzled

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By the time you get to work, you’re already feeling frazzled – and then your boss dumps an “urgent” project on your desk.
等到工作的时候，你已经早早的感到疲惫了——这时候你的上司把一个“紧急”任务放在你的桌面上。
When you eat mindlessly, while multitasking and in a frazzled state of mind, your digestive process is sluggish and results in poor uptake, indigestion and improper elimination.
如果是毫无目的的进食，头脑中会产生一种疲惫的状态，使得消化进程变得迟缓，有可能导致消化不良和排泄不正常。
It was childish nonsense - the chimerae of frazzled ganglia, or the unadvertised side effect of an anti-psychotic drug - but over the course of the summer, John and the Pilgrims became friends.
这是幼稚不可理喻的——由疲惫的神经中枢产生的幻想，或者是精神抑制药物未被声明的副作用——但是在这个夏天里，约翰和朝圣者成为了朋友。

Frazzled and furious women rage at their reclining-remote-grabbing men while so much work remains undone.
FORBES: Holidays: An Occasion for Crimes of the Heart
But when Elon Musk spoke to reporters afterward from California, he sounded frazzled.
NPR: SpaceX Makes Progress with Rocket Test
Today, the Wall Street Journal reported that Paulson held a second conference call with investors to sooth frazzled nerves.
FORBES: Paulson Calms Investors After SEC Charges Goldman

(TIRED) extremely tired in a nervous or slightly worried way after a lot of mental or physical effort
(BURNED) burned or dried out after being in the sun or cooking for too long

If you are frazzled, or if your nerves are frazzled, you feel mentally and physically exhausted.